Dirichlet-multinomial mixture models can be used to describe variability in microbial metagenomic data. This package is an interface to code originally made available by Holmes, Harris, and Quince, 2012, PLoS ONE 7(2): 1-15, as discussed further in the man page for this package, ?DirichletMultinomial.
Install DirichletMultinomial from Bioconductor with:
if (!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("DirichletMultinomial")Linux and MacOS with source-level installations require the 'gsl' system dependency. On Debian or Ubuntu
sudo apt-get install -y libgsl-dev
On Fedora, CentOS or RHEL
sudo yum install libgsl-devel
On macOS (source installations are not common on macOS, so this step may is not usually necessary)
brew install gsl
See the DirichletMultinomial Bioconductor landing page and vignette for use.