Merge branch 'master' into NTR-Melanin-concetrating-hormone-neuron-an…

…d-Molecular-layer-interneuron

src/mappings/fbbt.sssom.tsv

@@ -1,17 +1,17 @@
 #curie_map:
-#  CL: "http://purl.obolibrary.org/obo/CL_"
-#  FBbt: "http://purl.obolibrary.org/obo/FBbt_"
-#  ORCID: "https://orcid.org/"
-#  obo: "http://purl.obolibrary.org/obo/"
-#mapping_set_id: "http://purl.obolibrary.org/obo/fbbt/fbbt-mappings.sssom.tsv"
-#mapping_set_description: "Mappings between the Drosophila Anatomy Ontology and foreign ontologies."
+#  CL: http://purl.obolibrary.org/obo/CL_
+#  FBbt: http://purl.obolibrary.org/obo/FBbt_
+#  ORCID: https://orcid.org/
+#  obo: http://purl.obolibrary.org/obo/
+#mapping_set_id: http://purl.obolibrary.org/obo/fbbt/fbbt-mappings.sssom.tsv
+#mapping_set_description: Mappings between the Drosophila Anatomy Ontology and foreign ontologies.
 #creator_id:
-#  - "ORCID:0000-0002-1373-1705"
-#  - "ORCID:0000-0002-6095-8718"
-#license: "https://creativecommons.org/licenses/by/4.0/"
-#subject_source: "obo:fbbt.owl"
-#object_source: "obo:cl.owl"
-#mapping_date: "2024-07-12"
+#  - ORCID:0000-0002-1373-1705
+#  - ORCID:0000-0002-6095-8718
+#license: https://creativecommons.org/licenses/by/4.0/
+#subject_source: obo:fbbt.owl
+#object_source: obo:cl.owl
+#mapping_date: 2024-07-12
 subject_id	subject_label	predicate_id	object_id	mapping_justification
 FBbt:00000092	primordial germ cell	semapv:crossSpeciesExactMatch	CL:0000301	semapv:ManualMappingCuration
 FBbt:00000124	epithelial cell	semapv:crossSpeciesExactMatch	CL:0000066	semapv:ManualMappingCuration

src/ontology/Makefile

@@ -1,7 +1,7 @@
 # ----------------------------------------
 # Makefile for cl
 # Generated using ontology-development-kit
-# ODK Version: v1.5.2
+# ODK Version: v1.5.3
 # ----------------------------------------
 # IMPORTANT: DO NOT EDIT THIS FILE. To override default make goals, use cl.Makefile instead
 
@@ -10,7 +10,7 @@
 # More information: https://github.com/INCATools/ontology-development-kit/
 
 # Fingerprint of the configuration file when this Makefile was last generated
-CONFIG_HASH=                9b733c5ec38a935d574d153b99b0d69d2e8f730b562d33d8ece39a3917e022b7
+CONFIG_HASH=                54146b660b46ab72c0abd98ae67a46d194ff618c90da889ded7ed1b99fd74ae2
 
 
 # ----------------------------------------
@@ -46,7 +46,7 @@ REPORT_PROFILE_OPTS =
 OBO_FORMAT_OPTIONS =        
 SPARQL_VALIDATION_CHECKS =  equivalent-classes owldef-self-reference nolabels pmid-not-dbxref obsolete-replaced_by obsolete-alt-id orcid-contributor illegal-annotation-property label-synonym-polysemy illegal-date def-not-only-xref 
 SPARQL_EXPORTS =            cl_terms cl-edges cl-synonyms cl-xrefs cl-def-xrefs 
-ODK_VERSION_MAKEFILE =      v1.5.2
+ODK_VERSION_MAKEFILE =      v1.5.3
 
 TODAY ?=                    $(shell date +%Y-%m-%d)
 OBODATE ?=                  $(shell date +'%d:%m:%Y %H:%M')
@@ -102,7 +102,7 @@ release_diff: $(REPORTDIR)/release-diff.md
 
 .PHONY: reason_test
 reason_test: $(EDIT_PREPROCESSED)
-	$(ROBOT) reason --input $< --reasoner ELK --equivalent-classes-allowed asserted-only \
+	$(ROBOT) reason --input $< --reasoner WHELK --equivalent-classes-allowed asserted-only \
 		--exclude-tautologies structural --output test.owl && rm test.owl
 
 .PHONY: odkversion
@@ -854,9 +854,9 @@ ROBOT_RELEASE_IMPORT_MODE_BASE=$(ROBOT) remove --input $< --select imports --tri
 # base: A version of the ontology that does not include any externally imported axioms.
 $(ONT)-base.owl: $(EDIT_PREPROCESSED) $(OTHER_SRC) $(IMPORT_FILES)
 	$(ROBOT_RELEASE_IMPORT_MODE) \
-	reason --reasoner ELK --equivalent-classes-allowed asserted-only --exclude-tautologies structural --annotate-inferred-axioms False \
+	reason --reasoner WHELK --equivalent-classes-allowed asserted-only --exclude-tautologies structural --annotate-inferred-axioms False \
 	relax \
-	reduce -r ELK \
+	reduce -r WHELK \
 	remove --base-iri http://purl.obolibrary.org/obo/CP_ --base-iri http://purl.obolibrary.org/obo/CL_ --base-iri http://purl.obolibrary.org/obo/cl# --axioms external --preserve-structure false --trim false \
 	$(SHARED_ROBOT_COMMANDS) \
 	annotate --link-annotation http://purl.org/dc/elements/1.1/type http://purl.obolibrary.org/obo/IAO_8000001 \
@@ -865,9 +865,9 @@ $(ONT)-base.owl: $(EDIT_PREPROCESSED) $(OTHER_SRC) $(IMPORT_FILES)
 # Full: The full artefacts with imports merged, reasoned.
 $(ONT)-full.owl: $(EDIT_PREPROCESSED) $(OTHER_SRC) $(IMPORT_FILES)
 	$(ROBOT_RELEASE_IMPORT_MODE) \
-		reason --reasoner ELK --equivalent-classes-allowed asserted-only --exclude-tautologies structural \
+		reason --reasoner WHELK --equivalent-classes-allowed asserted-only --exclude-tautologies structural \
 		relax \
-		reduce -r ELK \
+		reduce -r WHELK \
 		$(SHARED_ROBOT_COMMANDS) annotate --ontology-iri $(ONTBASE)/$@ $(ANNOTATE_ONTOLOGY_VERSION) --output $@.tmp.owl && mv $@.tmp.owl $@
 # foo-non-classified: (edit->imports-merged)
 $(ONT)-non-classified.owl: $(EDIT_PREPROCESSED) $(OTHER_SRC) $(IMPORT_FILES)
@@ -878,12 +878,12 @@ $(ONT)-non-classified.owl: $(EDIT_PREPROCESSED) $(OTHER_SRC) $(IMPORT_FILES)
 #	remove --select imports --trim false
 $(ONT)-simple.owl: $(EDIT_PREPROCESSED) $(OTHER_SRC) $(SIMPLESEED) $(IMPORT_FILES)
 	$(ROBOT_RELEASE_IMPORT_MODE) \
-		reason --reasoner ELK --equivalent-classes-allowed asserted-only --exclude-tautologies structural --annotate-inferred-axioms False \
+		reason --reasoner WHELK --equivalent-classes-allowed asserted-only --exclude-tautologies structural --annotate-inferred-axioms False \
 		relax \
 		remove --axioms equivalent \
 		relax \
 		filter --term-file $(SIMPLESEED) --select "annotations ontology anonymous self" --trim true --signature true \
-		reduce -r ELK \
+		reduce -r WHELK \
 		query --update ../sparql/inject-subset-declaration.ru --update ../sparql/inject-synonymtype-declaration.ru \
 		$(SHARED_ROBOT_COMMANDS) annotate --ontology-iri $(ONTBASE)/$@ $(ANNOTATE_ONTOLOGY_VERSION) --output $@.tmp.owl && mv $@.tmp.owl $@
 
@@ -892,14 +892,14 @@ $(ONT)-simple.owl: $(EDIT_PREPROCESSED) $(OTHER_SRC) $(SIMPLESEED) $(IMPORT_FILE
 # removes any axioms that contains one of the ops that not in the whitelist file
 $(ONT)-basic.owl: $(EDIT_PREPROCESSED) $(OTHER_SRC) $(SIMPLESEED) $(KEEPRELATIONS) $(IMPORT_FILES)
 	$(ROBOT_RELEASE_IMPORT_MODE) \
-		reason --reasoner ELK --equivalent-classes-allowed asserted-only --exclude-tautologies structural --annotate-inferred-axioms False \
+		reason --reasoner WHELK --equivalent-classes-allowed asserted-only --exclude-tautologies structural --annotate-inferred-axioms False \
 		relax \
 		remove --axioms equivalent \
 		remove --axioms disjoint \
 		remove --term-file $(KEEPRELATIONS) --select complement --select object-properties --trim true \
 		relax \
 		filter --term-file $(SIMPLESEED) --select "annotations ontology anonymous self" --trim true --signature true \
-		reduce -r ELK \
+		reduce -r WHELK \
 		$(SHARED_ROBOT_COMMANDS) annotate --ontology-iri $(ONTBASE)/$@ $(ANNOTATE_ONTOLOGY_VERSION) --output $@.tmp.owl && mv $@.tmp.owl $@
 
 cl-plus.owl:

src/ontology/cl-edit.owl

@@ -3042,6 +3042,8 @@ Declaration(Class(obo:CL_4033085))
 Declaration(Class(obo:CL_4033086))
 Declaration(Class(obo:CL_4033087))
 Declaration(Class(obo:CL_4033088))
+Declaration(Class(obo:CL_4033089))
+Declaration(Class(obo:CL_4033090))
 Declaration(Class(obo:CL_4040000))
 Declaration(Class(obo:CL_4040001))
 Declaration(Class(obo:CL_4040002))
@@ -3089,6 +3091,7 @@ Declaration(Class(obo:CL_4047006))
 Declaration(Class(obo:CL_4047007))
 Declaration(Class(obo:CL_4047011))
 Declaration(Class(obo:CL_4047012))
+Declaration(Class(obo:CL_4047017))
 Declaration(Class(obo:CL_4047018))
 Declaration(Class(obo:CL_4047019))
 Declaration(Class(obo:CL_4047023))
@@ -3357,7 +3360,7 @@ AnnotationAssertion(rdfs:label obo:IAO_0000115 "definition")
 
 AnnotationAssertion(rdfs:label obo:IAO_0000424 "expand expression to")
 
-# Annotation Property: obo:IAO_0000700 (has ontology root term)
+# Annotation Property: obo:IAO_0000700 (preferred_root)
 
 AnnotationAssertion(rdfs:label obo:IAO_0000700 "preferred_root")
 
@@ -3451,11 +3454,11 @@ AnnotationAssertion(rdfs:label oboInOwl:hasBroadSynonym "has_broad_synonym")
 
 AnnotationAssertion(rdfs:label oboInOwl:hasDbXref "database_cross_reference")
 
-# Annotation Property: oboInOwl:hasExactSynonym (has exact synonym)
+# Annotation Property: oboInOwl:hasExactSynonym (has_exact_synonym)
 
 AnnotationAssertion(rdfs:label oboInOwl:hasExactSynonym "has_exact_synonym")
 
-# Annotation Property: oboInOwl:hasNarrowSynonym (has narrow synonym)
+# Annotation Property: oboInOwl:hasNarrowSynonym (has_narrow_synonym)
 
 AnnotationAssertion(rdfs:label oboInOwl:hasNarrowSynonym "has_narrow_synonym")
 
@@ -9421,7 +9424,7 @@ SubClassOf(obo:CL_0000677 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_000127
 
 # Class: obo:CL_0000678 (commissural neuron)
 
-AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:31693445") Annotation(oboInOwl:hasDbXref "PMID:17560562") obo:IAO_0000115 obo:CL_0000678 "A neuron with soma location in the central nervous system that project its axon to the contralateral side of a central nervous system. This neuron can have its soma in the spinal cord, in the hemisphere of the brain, in the retina or in the ventral nerve cord of invertebrates.")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:17560562") Annotation(oboInOwl:hasDbXref "PMID:31693445") obo:IAO_0000115 obo:CL_0000678 "A neuron with soma location in the central nervous system that project its axon to the contralateral side of a central nervous system. This neuron can have its soma in the spinal cord, in the hemisphere of the brain, in the retina or in the ventral nerve cord of invertebrates.")
 AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:25960414") Annotation(oboInOwl:hasDbXref "PMID:27532244") Annotation(oboInOwl:hasDbXref "PMID:31514748") Annotation(oboInOwl:hasDbXref "PMID:33438755") rdfs:comment obo:CL_0000678 "Historically, commissural neurons, particularly in the spinal cord, have been used as a model to understand axon guidance during development.")
 AnnotationAssertion(rdfs:label obo:CL_0000678 "commissural neuron")
 SubClassOf(obo:CL_0000678 obo:CL_0000540)
@@ -22921,7 +22924,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009011 "transit amplifying
 AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009011 "transit-amplifying cell of colon")
 AnnotationAssertion(oboInOwl:inSubset obo:CL_0009011 pato:location_grouping)
 AnnotationAssertion(rdfs:label obo:CL_0009011 "transit amplifying cell of colon")
-EquivalentClasses(obo:CL_0009011 ObjectIntersectionOf(obo:CL_0009010 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013485)))
+EquivalentClasses(obo:CL_0009011 ObjectIntersectionOf(obo:CL_4047017 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013485)))
 SubClassOf(obo:CL_0009011 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002250))
 
 # Class: obo:CL_0009012 (transit amplifying cell of small intestine)
@@ -22935,7 +22938,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009012 "transit amplifying
 AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009012 "transit-amplifying cell of small intestine")
 AnnotationAssertion(oboInOwl:inSubset obo:CL_0009012 pato:location_grouping)
 AnnotationAssertion(rdfs:label obo:CL_0009012 "transit amplifying cell of small intestine")
-EquivalentClasses(obo:CL_0009012 ObjectIntersectionOf(obo:CL_0009010 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001241)))
+EquivalentClasses(obo:CL_0009012 ObjectIntersectionOf(obo:CL_4047017 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0001241)))
 SubClassOf(obo:CL_0009012 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0002250))
 
 # Class: obo:CL_0009013 (fetal hepatobiliary progenitor cell)
@@ -23082,7 +23085,7 @@ AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009027 "transit amplifying
 AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009027 "transit amplifying cell of vermiform appendix")
 AnnotationAssertion(oboInOwl:inSubset obo:CL_0009027 pato:location_grouping)
 AnnotationAssertion(rdfs:label obo:CL_0009027 "transit amplifying cell of appendix")
-EquivalentClasses(obo:CL_0009027 ObjectIntersectionOf(obo:CL_0009010 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013486)))
+EquivalentClasses(obo:CL_0009027 ObjectIntersectionOf(obo:CL_4047017 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013486)))
 SubClassOf(obo:CL_0009027 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0009028))
 
 # Class: obo:CL_0009028 (intestinal crypt stem cell of appendix)
@@ -23379,7 +23382,7 @@ AnnotationAssertion(terms:contributor obo:CL_0009056 <https://orcid.org/0000-000
 AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_0009056 "anorectum transit amplifying cell")
 AnnotationAssertion(oboInOwl:inSubset obo:CL_0009056 pato:location_grouping)
 AnnotationAssertion(rdfs:label obo:CL_0009056 "transit amplifying cell of anorectum")
-EquivalentClasses(obo:CL_0009056 ObjectIntersectionOf(obo:CL_0009010 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_8410050)))
+EquivalentClasses(obo:CL_0009056 ObjectIntersectionOf(obo:CL_4047017 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_8410050)))
 
 # Class: obo:CL_0009057 (anorectum goblet cell)
 
@@ -32222,6 +32225,24 @@ AnnotationAssertion(rdfs:label obo:CL_4033088 "decidual resident macrophage")
 SubClassOf(obo:CL_4033088 obo:CL_4033087)
 SubClassOf(obo:CL_4033088 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002450))
 
+# Class: obo:CL_4033089 (atretic follicular cell of ovary)
+
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:38069168") obo:IAO_0000115 obo:CL_4033089 "A follicular cell of ovary that has begun to degenerate and undergo atresia, a specialized apoptosis. This cell is found in an atretic follicle, which is an ovarian follicle that started to mature but failed to reach full development and instead regresses.")
+AnnotationAssertion(terms:contributor obo:CL_4033089 <https://orcid.org/0000-0001-6677-8489>)
+AnnotationAssertion(terms:date obo:CL_4033089 "2024-11-05T11:23:25Z"^^xsd:dateTime)
+AnnotationAssertion(rdfs:label obo:CL_4033089 "atretic follicular cell of ovary")
+EquivalentClasses(obo:CL_4033089 ObjectIntersectionOf(obo:CL_0002174 ObjectSomeValuesFrom(obo:RO_0000056 obo:GO_0001552)))
+
+# Class: obo:CL_4033090 (atretic granulosa cell)
+
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:15353131") Annotation(oboInOwl:hasDbXref "PMID:38069168") obo:IAO_0000115 obo:CL_4033090 "A granulosa cell that is undergoing atresia. This cell type displays distinct morphological alterations compared with a healthy granulosa cell, including pyknosis (nuclear condensation) and cellular shrinkage.")
+AnnotationAssertion(terms:contributor obo:CL_4033090 <https://orcid.org/0000-0001-6677-8489>)
+AnnotationAssertion(terms:date obo:CL_4033090 "2024-11-05T11:25:28Z"^^xsd:dateTime)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:15353131") oboInOwl:hasRelatedSynonym obo:CL_4033090 "apoptotic granulosa cell")
+AnnotationAssertion(rdfs:label obo:CL_4033090 "atretic granulosa cell")
+SubClassOf(obo:CL_4033090 obo:CL_4033089)
+SubClassOf(obo:CL_4033090 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_0000501))
+
 # Class: obo:CL_4040000 (glial restricted tripotential precursor cell)
 
 AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:10719353") obo:IAO_0000115 obo:CL_4040000 "A glial precursor cell that generates oligodendrocytes and type-1 and type-2 astrocytes. It has been shown in some mammals that this cell type may express A2B5, nestin, FGFR-1, FGFR-2, FGFR-3, PLP, and DM-20 antigens. Unlike oligodendrocyte precursor cell, it does not initially express PDGFR-alpha and can differentiate into both type-1 and type-2 astrocytes.")
@@ -32761,6 +32782,18 @@ AnnotationAssertion(terms:date obo:CL_4047012 "2024-09-06T08:41:39Z"^^xsd:dateTi
 AnnotationAssertion(rdfs:label obo:CL_4047012 "angiogenic pericyte"@en)
 SubClassOf(obo:CL_4047012 obo:CL_0000669)
 
+# Class: obo:CL_4047017 (transit amplifying cell of gut)
+
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20683682") Annotation(oboInOwl:hasDbXref "PMID:33195268") Annotation(oboInOwl:hasDbXref "PMID:34497389") obo:IAO_0000115 obo:CL_4047017 "A transit amplifying cell of the gut epithelium, located in the wall of the intestinal crypt, just above intestinal stem cells from which they derive. These are rapidly dividing cells, capable of multiple rounds of division before differentiating into the various cell types of the gut epithelium (enterocyte, goblet, eneterodendocrine, paneth cells).")
+AnnotationAssertion(terms:contributor obo:CL_4047017 <https://orcid.org/0009-0005-7919-4905>)
+AnnotationAssertion(terms:date obo:CL_4047017 "2024-09-24T10:48:47Z"^^xsd:dateTime)
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:24813615") oboInOwl:hasBroadSynonym obo:CL_4047017 "transit-amplifying cell")
+AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:20683682") oboInOwl:hasRelatedSynonym obo:CL_4047017 "TA cell")
+AnnotationAssertion(rdfs:label obo:CL_4047017 "transit amplifying cell of gut"@en)
+EquivalentClasses(obo:CL_4047017 ObjectIntersectionOf(obo:CL_0009010 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0013740)))
+SubClassOf(obo:CL_4047017 obo:CL_0009010)
+SubClassOf(obo:CL_4047017 ObjectSomeValuesFrom(obo:RO_0002207 obo:CL_0002250))
+
 # Class: obo:CL_4047018 (early colonocyte)
 
 AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:28049136") Annotation(oboInOwl:hasDbXref "PMID:36060223") obo:IAO_0000115 obo:CL_4047018 "An enterocyte that is part of the colon, in the early stages of differentiation, located in the intestinal crypt-villus axis.")

src/ontology/cl-odk.yaml

@@ -98,6 +98,7 @@ pattern_pipelines_group:
   matches:
     - id: matches
 robot_java_args: '-Xmx16G'
+reasoner: WHELK
 allow_equivalents: asserted-only
 robot_report:
   release_reports: False

src/ontology/cl.Makefile

@@ -26,10 +26,10 @@ $(EDIT_PREPROCESSED): $(SRC) all_robot_plugins
 cl-plus.owl: $(ONT)-full.owl
 	$(ROBOT) merge -i $< -I $(OBOBASE)/pcl/pcl-base.owl \
 		 unmerge -I $(OBOBASE)/ncbitaxon/subsets/taxslim-disjoint-over-in-taxon.owl \
-		 reason --reasoner ELK --equivalent-classes-allowed asserted-only \
+		 reason --reasoner WHELK --equivalent-classes-allowed asserted-only \
 		        --exclude-tautologies structural \
 		 relax \
-		 reduce --reasoner ELK \
+		 reduce --reasoner WHELK \
 		 $(SHARED_ROBOT_COMMANDS) \
 		 annotate --ontology-iri $(ONTBASE)/$@ \
 		 $(ANNOTATE_ONTOLOGY_VERSION) --output $@
@@ -148,7 +148,7 @@ $(TMPDIR)/taxslim-disjoint-over-in-taxon.owl:
 $(REPORTDIR)/taxon-constraint-check.txt: $(EDIT_PREPROCESSED) $(TMPDIR)/taxslim-disjoint-over-in-taxon.owl
 	$(ROBOT) merge $(foreach src,$^,-i $(src)) \
 		 expand -o $(TMPDIR)/cl-plus-taxon-disjoints.ofn \
-		 reason -r ELK > $@
+		 reason -r WHELK > $@
 
 # Include the TC check in the routine tests
 test: $(REPORTDIR)/taxon-constraint-check.txt

src/ontology/imports/go_terms.txt

@@ -15,4 +15,4 @@ GO:1990573
 GO:0045428
 GO:0005927
 GO:0050893
-
+GO:0001552