[NTR] CGRP-expressing neuron

[AvolaAmg]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label

Synonyms (add reference(s), please)

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)

Your ORCID

Additional notes or concerns

[AvolaAmg]

@JABelfiore please review
definition:
An interneuron neuron characterized by the expression of calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide. This neuron type is involved in nociception and pain modulation by facilitating the transmission of nociceptive signals from peripheral sensory nerve endings to central nervous system structures. This neuron type is found in the dorsal root ganglia (DRG) and trigeminal ganglion, and the spinal cord dorsal horn.

references:
PMID: 34061020

references

synonyms:
CGRP-positive neuron

Calcitonin gene-related peptide neuron

CGRP-expressing interneurons
PMID: 34061020

[dosumis]

Check WMB neuropeptides to see if evidence for expression in more neuron types (There may be something similar for WHB). I think worth doing for all neurons defined by NPs.

[AvolaAmg]

From the ABC atlas WMB

From the ABC atlas Siletti data

In the Siletti data from CxG

CGPR expressing neurons are found in the spinal cord, DRG, trigeminal ganglion. These central nervous system structures are not within the brain, so this might be why this gene is not detectable in neurons from the encephalon.