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XBB.1.5.92 with ORF1a:L3829F (nsp6_L260F) (98 seqs, mainly in Costa Rica and Ecuador, 12 countries) #362
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Tracking updates: 07-11: 3 seqs from Panama, UK and USA1 from Wales, UK: 07-23: 3 seqs from Guatemala, Mexico and USA1 from Guatemala: 07-28: 9 seqs from China, UK, USA 08-08, 2 seqs from Ecuador and USA 08-18, 5 seqs from USA |
@AngieHinrichs As a sublineage of new-designated XBB.1.5.92, this lineage is placed under a Orf1a:Y1467C> Orf1a:T1168I> Orf1a:C1467Yrev flip-flop branch. And the sequences with C823T, C3768T, C10615T (parental branch of #170) are placed under C823T branch, but I think they are also a subbranch of XBB.1.5.92. |
There are at least three ecuadorean sublineage of XBB.1.5 with Orf1a:T1168I : |
ping @corneliusroemer see discussion above, please. |
@Over-There-Is I see that C3768T (ORF1a:T1168I) happens several times in XBB.1.5, but in each case there are more sequences with XBB.1.5 > [some mutation] than XBB.1.5 > [some mutation] > C3768T. So to me, the evidence for each of those other mutations occurring first looks pretty strong, and I think it's plausible that either C3768T happened multiple times after those other mutations (and perhaps is sometimes an artefact, especially from Ecuador and Sweden?). Why do you think the C823T, C3768T, C10615T sequences in particular belong in XBB.1.5.92? I see 134 sequences on the branch with all three of those mutations, but even more (207) that have C823T (but not C3768T and C10615T). Also some of the sequences with C823T have older dates like USA/MA-CDCBI-CRSP_YEAJAWGEG53EKBFX/2022|OP987449.1|2022-11-21. So I think it's plausible (though not certain) that C823T came first. |
Correcting mistake within <24hr
07-28: 9 seqs from China, UK, USA |
Last one from Texas. |
08-08, 2 seqs from Ecuador and USA: |
08-18, 5 from USA (NY, CA): |
gone stale |
Defining Mutations: XBB.1.5.92 (C3768T= ORF1a:T1168I) > C11750T(ORF1a:L3829F)
Query: C3768T, C11750T, T17124C
Earliest seq: 2023-03-06 (EPI_ISL_17240745, Ecuador)
Latest seq: 2023-06-23 (EPI_ISL_17961597, Ecuador)
Sampled Countries: Costa Rica (24), Ecuador (24), USA (12, California/5, New Jersey/2, New York/2, North Carolina/1, Pennsylvania/1, Texas/1), Guatemala (8), Germany (2), Belgium (1), Spain (1, Canary Islands), Colombia (1), Mexico (1), Panama (1), UK (1, Wales)
Genomes:
EPI_ISL_17240745, EPI_ISL_17429082, EPI_ISL_17519027,
EPI_ISL_17519102, EPI_ISL_17525650, EPI_ISL_17527944,
EPI_ISL_17527949, EPI_ISL_17582793-17582796, EPI_ISL_17582798,
EPI_ISL_17582806, EPI_ISL_17612038, EPI_ISL_17612061,
EPI_ISL_17621288, EPI_ISL_17654589, EPI_ISL_17654598,
EPI_ISL_17654687, EPI_ISL_17654750, EPI_ISL_17654777,
EPI_ISL_17654789, EPI_ISL_17674267, EPI_ISL_17683020,
EPI_ISL_17683043-17683044, EPI_ISL_17684571, EPI_ISL_17684577,
EPI_ISL_17695468, EPI_ISL_17695472, EPI_ISL_17712005,
EPI_ISL_17712018, EPI_ISL_17713984, EPI_ISL_17722436,
EPI_ISL_17730094, EPI_ISL_17763506, EPI_ISL_17766883,
EPI_ISL_17774107, EPI_ISL_17774126, EPI_ISL_17774131,
EPI_ISL_17774145, EPI_ISL_17774195-17774196, EPI_ISL_17774198,
EPI_ISL_17774203-17774207, EPI_ISL_17788960, EPI_ISL_17798393,
EPI_ISL_17800566, EPI_ISL_17801644, EPI_ISL_17833803,
EPI_ISL_17833855, EPI_ISL_17833862, EPI_ISL_17834337,
EPI_ISL_17834418, EPI_ISL_17838695, EPI_ISL_17854201,
EPI_ISL_17854470, EPI_ISL_17856036, EPI_ISL_17879866,
EPI_ISL_17950535, EPI_ISL_17954111, EPI_ISL_17954147,
EPI_ISL_17954610, EPI_ISL_17961499, EPI_ISL_17961554,
EPI_ISL_17961593, EPI_ISL_17961597, EPI_ISL_17961609,
EPI_ISL_17961637, EPI_ISL_17970749, EPI_ISL_17972754,
EPI_ISL_17972779
UShER:
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3eab3_97aef0.json?f_userOrOld=uploaded%20sample
view from XBB.1.5's T17124C polytomy
details
Trivia:
Probably high local prevalence in certain South America countries, too little samples to confirm this.
ORF1a:L3829F is the notorious chronic infection hallmark, this may be worth monitoring for a while.
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